Version 2.32
Leading-Edge Features
Special Features
Special Analysis Features
Ordinary Features
Additional Features
Papers using WinLTP and/or the LTP Program
(to 11 February, 2020)


WinLTP and the LTP Program has been used in at least 714 publications from labs in China, Finland, France, Germany, Israel, Italy, Japan, Korea, Portugal, Russia, Saudi Arabia, Spain, Switzerland, UK and USA, and from 6 labs from the University of Bristol.

If you have published a paper using WinLTP or the LTP Program and it is not listed below would you please email us the publication name.  Many thanks to those who referenced these programs.  



WinLTP has been used in at least 333 publications.


333.  Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, Sharma E, Quesnel-Vallières M, Permanyer J, Maier S, Georgiou J, Irimia M, Sonenberg N, Forman-Kay JD, Gingras A-C, Collingridge GL, Woodin MA, Cordes SP and Blencowe BJ  (2020)  Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.  Molecular Cell,

332.  Poirel O, Mamer LE, Herman MA, Arnulf-empcke M, Kervern M, Potier B, Miot M, Wang J, Favre-Besse F-C, Brabet I, Laras Y, Bertrand H-O, Acher F, Pin J-F, Puel J-l, Giros B, Epelbaum J, Rosenmund C, Dutar P, Daumas S, Mestikawy SE and Pietrancosta N  (2020)  LSP5-2157 a new inhibitor of vesicular glutamate transporters. Neuropharmacology, 164:107902;

331.  Ramasamy VS, Samidurai M, Park HJ, Wang M, Park RY, Yu SY, Kang HK, Hong S, Choi W-S, Lee yy, Kim H-S and Jo J  (2020)  Avenanthramide-C Restores Impaired Plasticity and Cognition in Alzheimer’s Disease Model Mice. Molecular Neurobiology, 57:315–330;

330.  Sanders B, D’Andrea D, Collins MO, Rees E, Steward TGJ, Zhu Y, Chapman G, Legge SE, Pardiñas AF, Harwood AJ, Gray WP, O’Donovan MC, Owen MJ, Errington AC, Blake DJ, Whitcomb DJ, Pocklington AJ and Shin E  (2020)  Synaptic protein DLG2 controls neurogenic transcriptional programs disrupted in schizophrenia and related disorders.  bioRxiv,



329.  Abdel-Rahman EA, Bhattacharya S, Buabeid M, Majrashi M, Bloemer J, Tao Y-X, Dhanasekaran M, Escobar M, Amin R and Suppiramaniam V  (2019)  PPAR-d Activation Ameliorates Diabetes-Induced.  Cognitive Dysfunction by Modulating Integrin-linked Kinase and AMPA Receptor Function.  Journal of the American College of Nutrition, 38:693-702;

328.  Alhowail AH, Bloemer J, Majrashi M, Pinky PD, Bhattacharya S, Yongli Z, Bhattacharya D, Eggert M, Woodie L, Buabeid MA, Johnson J, Broadwater A, Smith B, Dhanasekaran M, Arnold RD and Suppiramaniam V (2019) Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation.  Toxicology Mechanisms and Methods,

327. Amici M, Lee Y, Pope RJP and Collingridge GL (2019)  GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα.  bioRxiv, doi:

326.  Bloemer J, Pinky PD, Smith WD Bhattacharya D, Chauhan A, Govindarajulu M, Hong H, Dhanasekaran M. JuddR, Amin RH, Reed MN and Suppiramaniam V  (2019)  Adiponectin Knockout Mice Display Cognitive and Synaptic Deficits. Front. Endocrinol.,

325.  Boccella S, Cristiano C, Romano R, Iannotta M, Belardo C, Farina A, Guida F, Piscitelli F, Palazzo E, Mazzitelli M, Imperatore R, Tunisi L, de Novellis V, Cristino L, Di Marzo V, Calignano A, Maione S and Luongo L  (2019)  Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.  Neurobiology of Disease, 121:106-119.

324.  Boccella S, Marabese I, Iannotta M, Belardo C, Neugebauer V, Mazzitelli M, Pieretti G, Maione S and Palazzo E (2019)  Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain.  Int. J. Mol. Sci., 20:1757;

323.  Broad LM, Sanger HE, Mogg AJ, Colvin EM, Zwart R, Evans DA, Pasqui F, Sher E, Wishart GN, Barth VN, Felder CC and Goldsmith PJ  (2019)  Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors.  Brit. J. Pharmacol., 176:110-126.

322.  Bürge M, Kratzer S, Mattusch C, Hofmann C, Kreuzer M, Parsons CG and Rammes G  (2019)  The anaesthetic xenon partially restores an amyloid beta-induced impairment in murine hippocampal synaptic plasticity. Neuropharmacology,

321.  Casarotto PC, Girych M, Fred SM, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Laukkanen L, Cardon I, Antila H, Rog T, Bramham CR, Normann C, Lauri SE, Vattulainen I and Castrén E  (2019)  Antidepressants act by binding to the cholesterol-interaction site at TRKB neurotrophin receptor. bioRxiv.

320. Cheon M, Park H, Rhim H and Chung CH  (2019)  Actions of Neuropeptide Y on Synaptic Transmission in the Lateral Habenula.  Neuroscience, 410:183-190.

319. Chang EH, Carreiro ST, Frattini SA and Huerta PT  (2019)  Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches.  Bioelectronic Medicine,

318.  Clements L and Harvey J  (2019)  Activation of oestrogen receptor a induces a novel form of LTP at hippocampal temporoammonic-CA1 synapses.  Brit. J. Pharmacol.,

317.  Duarte JMN, Skoug C, Silva HB, Carvalho RA, Gruetter R and Cunha RA  (2019)  Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus.  Front. Neurosci.,

316. Dutar P and Potier B (2019) Susceptibility to Aβo and TBOA of LTD and Extrasynaptic NMDAR-Dependent Tonic Current in the Aged Rat Hippocampus. Neurochemical Research, 44:692–702.

315.  Dutar P, Tolle V, Kervern M, Carcenac C, Carola V, Gross C, Savasta M, Darmon M and Masson J  (2019)  GLS1 Mutant Mice Display Moderate Alterations of Hippocampal Glutamatergic Neurotransmission Associated with Specific Adaptive Behavioral Changes.  Neuroscience, 396:175-186.

314.  Farmer LK, Rollason R, Whitcomb DJ, Ni L, Goodliff A, Lay AC, Birnbaumer L, Heesom KJ, Xu S-Z, Saleem MS and Welsh HI  (2019)  TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility.  JASN, 30:1910-1924;

313.  Farris S, Ward JM, Carstens KE, Samadi M, Wang Y and Dudek SM  (2019)  Hippocampal Subregions Express Distinct Dendritic Transcriptomes that Reveal Differences in Mitochondrial Function in CA2.  Cell Reports, 29:522-539.e6;

312.  Figueiredo CP, Barros-Aragão FGQ, Neris RLS, Frost PS, Soares C, Souza INO, Zeidler JD, Zamberlan DC, de Sousa VJ, Souza AS, Guimarães ALA, Bellio M, de Souza JM, Alves-Leon SV, Neves GA, Paula-Neto HA, Castro NG, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT and Ferreira ST  (2019)  Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.  Nat. Commun., 10,3890;

311.  Gonçalves FQ, Lopes JP, Silva HB, Lemos C, Silva AC, Gonçalves N, Tomé AR, Ferreira SG, Canas P, Rial D, Agostinho P, Cunha RA (2019) Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine.  Neurobiology of Disease, 132:104570.

310.  Hoeller AA, Lach G, Costa APR, Walz R, Bortolotto ZA and De Lima TCM  (2019)  Hippocampus-dependent fear conditioning is not sensitized by muscarinic receptor activation following systemic injection of pilocarpine.  Neurology, Psychiatry and Brain Research, 34:44-49;

309.  Huang Y, Li D, Cheng B, Liu G, Zhang Y-X and Zhou W-X  (2019)  Active fraction combination from Liuwei Dihuang decoction (LW-AFC) ameliorates corticosterone-induced long-term potentiation (LTP) impairment in mice in vivo.  Journal of Ethnopharmacology, 236:147-154.

308.  Lecca D, Bader M, Tweedie D, Hoffman AF, Jung YJ, Hsueh S-C, Hoffer BJ, Becker RE, Pick CG, Lupica CR and Greig NH  (2019)  (-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice. Neurobiology of Disease, 130:104528;

307.  Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL and Kennedy MJ  (2019)  A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission.  Neuron, 101:863-875.e6;

306. Lopes JP, Pliássova A and Cunha RA  (2019)  The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors.  Biochem. Pharmacol., 166:313-321.

305.  Marinha LS, Castanho I, Silva RB, Bravo FV, Miranda AM, Xu Y, Point du Jour K, Wenk M, Chan RM, Di Paolo G, Pinto V and Oliveira TG  (2019)  Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning.  Cell Reports.

304.  Molchanova SM, Mariia Cherepkova, Shamsiiat Abdurakhmanova, Suvi Kuivanen, Elina Pörsti, Päivi A. Pöhö, Jaakko S. Teppo, Jonna Saarimäki-Vire, Jouni Kvist, Diego Balboa, Andrii Domanskyi, Raul R. Gainetdinov, Petteri Piepponen, Markku Varjosalo, Risto Kostiainen, Olli Vapalahti, Tomi P. Taira, Timo Otonkoski, Maxim M. Bespalov  (2019)  Maturation of Neuronal Activity in Caudalized Human Brain Organoids.  bioRxiv,

303. Morató X, Gonçalves FQ, Lopes JP, Jauregui O, Soler C, Fernández-Dueñas V, Cunha RA and Ciruela F  (2019)  Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice.  J. Neurochem.,

302.  Muzzi M, Zecchi R, Ranieri G, Urru M, Tofani L, De Cesaris F, Panconesi A and Chiarugi A  (2019)  Ultra-rapid brain uptake of subcutaneous sumatriptan in the rat: Implication for cluster headache treatment. Cephalalgia,

301.  Nakamura Y, Dryanovski DI, KimuraY, Jackson SN, Woods AS, Yasui Y, Tsai S-Y, Patel S, Covey DP, Su T-P and Lupica CR  (2019)  Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion.  eLife 2019;8:e47209;

300.  Ochiishi T, Kaku M, Kiyosue K, Doi M, Urabe T, Hattori N, Shimura H and Ebihara T  (2019)  New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid ß oligomers.  Scientific Reports, 9:17368;,

299. Oh ST, Liu QF, Jeong HJ, Lee S, Samidurai M, Jo J, Pak SC, Park H-J, Kim J and Jeon S (2019) Nasal Cavity Administration of Melanin-Concentrating Hormone Improves Memory Impairment in Memory-Impaired and Alzheimer’s Disease Mouse Models. Molecular Neurobiology, 56:8076–8086.

298.  Orav E, Ilona Dowavic, Johanna Huupponen, Tomi Taira & Sari E. Lauri  (2019)  NETO1 Regulates Postsynaptic Kainate Receptors in CA3 Interneurons During Circuit Maturation.  Molecular Neurobiology, 56:7473–7489;

297.  Park K and Chung CH  (2019)  Differential Alterations in Cortico-Amygdala Circuitry in Mice with Impaired Fear Extinction. Molecular Neurobiology,

296.  Park P, Kang H, Sanderson TM, Bortolotto ZA, Georgiou J, Zhuo M, Kaang B-K and Collingridge GL  (2019)  On the Role of Calcium-Permeable AMPARs in Long-Term Potentiation and Synaptic Tagging in the Rodent Hippocampus.  Front. Synaptic Neurosci., 11:4; doi: 10.3389/fnsyn.2019.00004.

295.  Pickford J, Apps R and Bashir ZI  (2019)  Muscarinic Receptor Modulation of the Cerebellar Interpositus Nucleus In Vitro.  Neurochemical Research, 44:627–635.

294.  Pierrot N, Ris L, Stancu I-C, Doshina A, Ribeiro F, Tyteca D, Baugé E, Lalloyer F, Malong L, Schakman O, Leroy K, Kienlen-Campard P, Gailly P, Brion J-P, Dewachter I, Staels B and Octave J-N   (2019)  Sex-regulated gene dosage effect of PPARα on synaptic plasticity.  Life Science Alliance, DOI10.26508/lsa.201800262.

293.  Pinto-Duarte A, Roberts AJ, Ouyang K, Sejnowski TJ  (2019)  Impairments in remote memory caused by the lack of Type 2 IP3 receptors.  Glia,

292.  Privitera L, Hogg EL, Gaestel M, Wall MJ and Corrêa SAL  (2019)  The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning.  Neuropharmacology, 155:121-130;

 291. Reis SL, Silva HB,  Almeida M, Cunha RA, Simões AP and Canas PM  (2019)  Adenosine A1 and A2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus.  J. Neurochem.

290.  Ruhl DA, Bomba-Warczak E, Watson ET, Bradberry MM, Peterson TA, Basu T, Frelka A, Evans CS, Briguglio JS, Basta T, Stowell MHB, Savas JN, Roopra A, Pearce RA, Piper RC and Chapman ER  (2019)  Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.  Nature Communications, 10:3532;

289.  Ryu H-H, Kim TH, Kim J-W, Kang M, Park P, Kim YG, Kim H, Ha J, Choi JE, Lee J, Lim C-S, Kim C-H, Kim SJ, Silva AJ, Kaang B-K and Lee Y-S  (2019)  Excitatory neuron–specific SHP2-ERK signaling network regulates synaptic plasticity and memory.  Science Signaling 12, eaau5755.

288. Schiffino FL, Siemian JN, Petrella M, Laing BT, Sarsfield S, Borja CB, Gajendiran A, Zuccoli ML and Aponte Y (2019) Activation of a lateral hypothalamic-ventral tegmental circuit gates motivation.  PLoS One, 14(7):e0219522, doi: 10.1371/journal.pone.0219522

287. Tsokas P, Rivard B, Hsieh C, Cottrell JE, Fenton AA and Sacktor TC (2019)  Antisense Oligodeoxynucleotide Perfusion Blocks Gene Expression of Synaptic Plasticity-related Proteins without Inducing Compensation in Hippocampal Slices.  Bio Protoc. 9:e3387, doi:10.21769/BioProtoc.3387.

286.  van Diggelen F, Hrle D, Apetri M, Christiansen G, Rammes G, Tepper A and Otzen DE  (2019)  Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.  PLOS|ONE,

285.  Wallach J, Colestock T, Agramunt J, Claydon MDB, Dybek M, Filemban N, Chatha M, Halberstadt A;. Brandt SD, Lodge D, Bortolotto ZA and Adejare A  (2019)  Pharmacological characterizations of the 'legal high' fluorolintane and isomers. Eur. J. Pharmacol., 857:172427,

284.  Wallach J, Kavanagh PV, Mclaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM and Brandt SD  (2019)  Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers.

283. Wang M, Ramasamy VS, Samidurai M and Jo J (2019)  Acute restraint stress reverses impaired LTP in the hippocampal CA1 region in mouse models of Alzheimer’s disease.  Scientific Reports, 9: 10955;

282.  Wild AR, Sinnen BL, Dittmer PJ, Kennedy MJ, Sather WA and Dell’Acqua ML  (2019)  Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma.  Cell Reports, 26:3537-3550.e4;

281.  Zhou L-J, Peng J, Xu Y-N, Zeng W-J, Zhang J, Wei X, Mai C-L, Lin C-J, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin W-J, Chen T, Li M, Wang H, Richardson JR, Tan Z, Liu X-J and Wu L-J  (2019)  Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Reports, 27:3844-3859.e6.



280.  Al-Osta I, Mucha M, Pereda D and Piqué-Gili P  (2018)  Imaging calcium in hippocampal presynaptic terminals with a ratiometric calcium sensor in a novel transgenic mouse.  Front. Cell. Neurosci., 12:209; doi: 10.3389/fncel.2018.00209.

279.  Amorim IS, Kedia S, Kouloulia S, Simbriger K, Gantois I, Jafarnejad SM, Li Y, Kampaite A, Pooters T, Romano N and Gkogkas CG (2018)  Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation.  J. Neuroscience, 38:2118–2133,

278.  Androuin A, Potier B, Nägerl UV, Cattaert D, Danglot L, Thierry M, Youssef I, Triller A, Duyckaerts C, El Hachimi KH, Dutar P, Delatour B and Marty S  (2018)  Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model.  Acta Neuropathologica,

 277.  Audrain M, Souchet B, Alves S, Fol R, Viode A, Haddjeri A, Tada S, Orefice NS, Joséphine C, Bemelmans A-P,  Delzescaux T, Déglon N, Hantraye P, Akwa Y, Becher F, Billard J-M,, Potier B, Dutar P, Cartier N and Braudeau J  (2018)βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease.  Cerebral Cortex, 28: 3976–3993.

276. Bian C, Huang Y, Zhu H, Zhao Y, Zhao J, Zhang J  (2018)  Steroid Receptor Coactivator-1 Knockdown Decreases Synaptic Plasticity and Impairs Spatial Memory in the Hippocampus of Mice.

275.  Billard JM and Freret T  (2018)  Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA 3/CA 1 synapses.  J. Neurochem., 147:514-525;

274.  Buonvicino D, Felici R, Ranieri G and Caramelli R  (2018)  Effects of Class II-Selective Histone Deacetylase Inhibitor on Neuromuscular Function and Disease Progression in SOD1-ALS Mice. Neuroscience, 379:228-238;

273.  Carvajal FJ, Mira RG, Rovegno M, Minniti AM and Cerpaa W  (2018)  Age-related NMDA signaling alterations in SOD2 deficient mice.  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (in press);

272.  Choi JE, Kim S, Lee J and Kim K  (2018)  Circadian Regulation by REV-ERBa Mediates Hippocampal E-LTP in a Time-dependent Manner.  Exp. Neurobiol., 27:344-349;

271. Datunashvili1 M, Chaudhary R, Zobeiri M, Lüttjohann A, Mergia E, Baumann A, Balfanz S, Budde B, van Luijtelaar G, Pape H-C, Koesling D and Budde T  (2018)  Modulation of hyperpolarization-activated inward current and thalamic activity modes by different cyclic nucleotides.  Front. Cell. Neurosci., .

270.  Daudin R, Marechal D, Wang Q, Abe Y, Bourg N, Sartori M, Loe-Mie Y, Lipecka J, Guerrera C, McKenzie A, Potier B, Dutar P, Viard J, Lepagnol-Bestel A-M, Winkeler A, Hindie V, Birling M-C, Lindner L, Chevalier C, Pavlovic G, Reiss M, Kranz H, Dupuis G, Leveque-Fort S, Diaz J, Davenas E, Dembele D, Laporte J, Thibault-Carpentier C, Malissen B, Rain J-C, Ciobanu L, Le Bihan D, Zhang B, Herault Y and Simonneau M  (2018)  BIN1 genetic risk factor for Alzheimer is sufficient to induce early structural tract alterations in entorhinal cortex-dentate gyrus pathway and related hippocampal multi-scale impairments.  BioRxiv,

269.  Domenici MR, Chiodi V, Averna M, Armida M, Pèzzola A, Pepponi R, Ferrante A, Bader M, Fuxe K and Popoli P (2018)  Neuronal adenosine A2A receptor overexpression is neuroprotective towards 3-nitropropionic acid-induced striatal toxicity: a rat model of Huntington's disease.  Purinergic Signalling, 14:235–243;

268.  Dutar P and Potier B  (2018)  Susceptibility to Aßo and TBOA of LTD and Extrasynaptic NMDAR-Dependent Tonic Current in the Aged Rat Hippocampus.  Neurochem. Res.

267.  Hall J and Frenguelli BG  (2018)  The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence for the rapid depletion of cellular ATP during electrographic seizures.  J. Neurochem., 147,:178-189;

266.  Hundehege P, Fernandez-Orth J, Römer P, Ruck T, Müntefering T, Eichler S, Cerina M, Epping L, Albrecht S, Menke AF, Birkner K, Göbel K, Budde T, Zipp F, Wiendl H, Gorji A, Bittner S and Meuth SG  (2018)  Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis.  Neurosignals, 26:77–93;

265.  Ingram R, Kang H, Lightman S, Jane DE, Bortolotto ZA, Collingridge GL, Lodge D and Volianskis A  (2018)  Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity.  Neuropharmacology, 142:30-40;

264.  Kerkhofs A, Canas PM, Timmerman AJ, Heistek TS, Real JI, Xavier C, Cunha RA, Mansvelder HD and Ferreira SG (2018)  Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex.  Front. Pharmacol., 20 March 2018,

263.  Kim S, Yu NK, Shim KW, Kim J, Kim H, Han DH, Choi JE, Lee S-W, Choi DI, Kim MW, Lee D-S, Lee K, Galjart N, Lee Y-S, Lee J-H and Kaang B-K  (2018)  Remote memory and cortical synaptic plasticity require neuronal CCCTC-binding factor (CTCF).  J. Neuroscience, 38:5042–5052.

262.  Lepannetier S, Gualdani R, Tempesta S, Schakman 0, Seghers F, Kreis A, Yerna X, Slimi A, de Clippele M, Tajeddine N, Voets T, Bon RS, Beech DJ, Tissir F and Gailly P  (2018)  Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory. Front.  Cell. Neurosci., 12:318; doi: 10.3389/fncel.2018.00318.

261. Manz KM, Levine WA, Seckler JC, Iskander AN and Reich CG  (2018)  A novel adolescent chronic social defeat model: reverse-Resident-Intruder Paradigm (rRIP) in male rats.  International Journal on the Biology of Stress, 21:169-178,

260.  Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M and Palop JJ  (2018)  Neuron, in press;

259.  McGregor G, Clements L, Farah A, Irving AJ and Harvey J  (2018)  Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin.  Neurobiology of Aging, 69:76-93.

258.  Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang G-J, Volkow ND and Hurd YL  (2018) Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity.  Mol Psychiatry, doi: 10.1038/s41380-018-0120-7.

257. Mlinar B and Corradetti R  (2018)  Differential modulation of CA1 impulse flow by endogenous serotonin along the hippocampal longitudinal axis.  Hippocampus,

256.   Morató X, Gonçalves FQ, Lopes JP, Jauregui O, Soler C, Fernández‐Dueñas V, Cunha RA and Ciruela F  (2018) Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD in GPR37 deficient mice.  J. Neurochem.,

255.  Morel C, Sherrin T, Kennedy NJ, Forest KH, Barutcu SA, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, Benveniste M, Davis RJ and Todorovic C  (2018)  JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. Journal of Neuroscience, 14 March 2018, 1913-17;

254. Muzzi M, Gerace E, Buonvicino D, Coppi E, Francesco Resta 2, Formentini L, Zecchi R, Tigli L, Guasti D, Ferri M, Camaioni E, Masi A, Pellegrini-Giampietro DE, Mannaioni G, Bani D, Pugliese AM and Chiarugi A (2018) 

253.  Park HJ, Kang H, Jo J, Chung E and Kim S  (2018)  Planar coil-based contact-mode magnetic stimulation: synaptic responses in hippocampal slices and thermal considerations.  Scientific Rreports, 8, Article number: 13423.

252.  Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J and Dell’Acqua ML  (2018)  AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP.  Cell Reports, 25:P74-987.e4;

251.  Rajgor D, Sanderson TM, Amici M, Collingridge GL and Hanley JG  (2018)  NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity.  The EMBO Journal, 37:e97943|2018.

250.  Real JI, Simões AP, Cunha RA, Ferreira SG and Rial D  (2018)  Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex. Eur. J. Neuroscience, 47:1127–1134.

249.  Sabec MH, Wonnacott S, Warburton EC and Bashir ZI  (2018)  Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex.  Cell Reports, 22:3409-3415.

248. Samidurai M, Ramasamy VS and Jo J (2018) ß-amyloid inhibits hippocampal LTP through TNFR/IKK/NF-?B pathway. Neurological Research, 40:268-276,

247.  Sanderson TM, Bradley CA, Georgiou J, Hong YH, NaNg A, Lee Y, Kim H-D, Kim D, Amici M, Son GH, Zhuo M, Kim K, Kaang B-K, Kim SJ and Collingridge GL  (2018)  The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.  Cell Reports, 25:3631-3646.e3.

246.  Silva AC, Lemos C, Gonçalves FQ, Pliássova AV, Machadoa NJ, Silvaa HB, Canas PM, Cunha RA, Lopes JP and Agostinho P  (2018)  Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease.  Neurobiology of Disease, 117:72-81.

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67. Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TMK, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD and Bahn S  (2012) The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus.  Neuropsychopharmacology, 37:364–377

66. Huang Y, Yang S, Hu Z-Y, Liu G, Zhou W-X and Zhang Y-X  (2012)  A new approach to location of the dentate gyrus and perforant path in rats/mice by landmarks on the skull  Acta Neurobiol. Exp., 468–472.

65. Huang Y, Zhang H, Yang S, Qiao H, Zhou W and Zhang Y  (2012)  Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors. J. Ethnopharm., 140:384–390.

64.  Huupponen, J, Molchanova SM, Lauri SE and Taira T  (2012)  Ongoing intrinsic synchronous activity is required for the functional maturation of CA3-CA1 glutamatergic synapses.  Cerebral Cortex, doi: 10.1093/cercor/bhs262.

63. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y  (2012)  Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development.  PLoS ONE 7(9): e46340. doi:10.1371/journal.pone.0046340.

62. Kaindl AM, Degos V, Peineau S, Gouadon E, Chhor V, Loron G, Le Charpentier T, Josserand J, Ali C, Vivien D, Collingridge GL, Lombet A, Issa L, Rene F, Loeffler JP, Kavelaars A, Verney C, Mantz J and Gressens P  (2012)  Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain.  Ann. Neurology, 72:536–549.

61. Kratzer S, Mattusch C, Kochs E, Eder M, Haseneder R and Rammes Gerhard  (2012)  Xenon Attenuates Hippocampal Long-term Potentiation by Diminishing Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Currents. Anesthesiology, 116:673-682.

  • 60. Lucas SJ, Bortolotto ZA, Collingridge GL and Lodge D  (2012)  Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala.  Neuropharmacology, in press.

59. Luchkina NV, Sallert M, Clarke VRJ, Taira T and Lauri SE  (2012)  Mechanisms underlying induction of LTP-associated changes in short-term dynamics of transmission at immature synapses.  Neuropharmacol., 67:494-502.

58. Muzzi M, Blasi F, Masi A, Coppi E, Traini C, Felici R, Pittelli M, Cavone L, Pugliese AM, Moroni F and Chiarugi A  (2012)  Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia.  J. Cerebral Blood Flow & Metabolism, doi:10.1038/jcbfm.2012.157.

57. Nicolas CS, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, Collett VJ, Hildebrandt L, Seaton G, Choi S-L, Sim S-E, Bradley C, Lee K, Zhuo M, Kaang B-K, Gressens P, Dournaud P, Fitzjohn SM, Bortolotto ZA, Cho K and Collingridge GL  (2012)  The JAK/STAT Pathway Is Involved in Synaptic Plascity.  Neuron, 73:374–390.

56. Nuritova F and Frenguelli BG  (2012)  Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors.  Neurosci., 222:159-172.

  • 55. Panaccione I, King R, Molinaro G, Riozzi B, Battaglia G, Nicoletti F and Bashir ZI  (2012) Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex.  Neuropharmacology, in press.

54. Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM, Briens A, Hommet Y, Wu J, Yepes M, Lijnen HR, Dutar P, Anglés-Cano E and Vivien  (2012)  Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.  Cell Death & Differentiation, 19:1983-1991.

53. Portelli J, Thielemans L, Ver Donck L, Loyens E, Coppens J, Aourz N, Aerssens J, Vermoesen K, Clinckers R, Schallier A, Michotte Y, Moechars D, Collingridge GL, Bortolotto ZA and Smolders I  (2012)  Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents. Neurotherapeutics, 9:658-672.

52. Regnier V, Billard J-M, Gupta S, Potier B, Woerner S, Paly E, Aurelie Ledru, David S, Luilier S, Bizot J-C, Vacano G, Kraus JP, Patterson D, Kruger WD, Delabar JM, London J (2012) Brain Phenotype of Transgenic Mice Overexpressing Cystathionine b-Synthase. PLOS ONE, 7:e29056.

51. Romberg C, McTighe SM, Heath CJ, Whitcomb DJ, Cho K, Bussey TJ and Saksida LM  (2012)  False recognition in a mouse model of Alzheimer’s disease: rescue with sensory restriction and memantine.  Brain, doi:10.1093/brain/aws074.

50.  Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu G-Q, Palop JJ and Mucke L  (2014)  Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model.  Proc. Nat Acad Sci., 109:2895-2903.

49. Sanderson TM, Cotel MC, O’Neill MJ, Tricklebank MD, Collingridge GL and Sher E  (2012)  Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia.  Neuropharmacology, 62:1349-1358.

48. Scott   HL, Tamagnini F, Narduzzo KE, Howarth JL, Lee YB, Wong LF, Brown MW, Warburton EC, Bashir ZI and Uney JB  (2012)  MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.  Eur. J Neurosci., 36: 2941–2948.

47. Sherwood JL, Amici M, Dargan SL, Culley GR, Fitzjohn SM, Jane DE, Collingridge GL, Lodge D, Bortolotto ZA  (2012)  Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation.  Neurochemistry International, 61:482-489.

46. Shonesy BC, Thiruchelvam K, Parameshwaran K, Rahman EA, Karuppagounder SS, Huggins KW, Pinkert CA, Amina R,  Dhanasekaran M and Suppiramaniam V  (2012)  Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents.  Neurobiology of Aging, 33:430.e5– 430.e18.

45. Srivastava R, Kumar M, Peineau S, Csaba Z, Mani S, Gressens P, El Ghouzzi V  (2012)  Conditional induction of Math1 specifies embryonic stem cells to cerebellar granule neuron lineage and promotes differentiation into mature granule neurons.  Stem Cells,  31:652–665.

44. Supcun B, Ghadiri MK, Zeraati M, Stummer W, Speckmann EJ, Gorji A  (2012)  The effects of tetanic stimulation on plasticity of remote synapses in the hippocampus-perirhinal cortex-amygdala network.  Synapse, 66:965-974.

43. Titus DJ, Furones C, Kang Y,  Atkins CM  (2013)  Age-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injury.  Neuroscience, 231:182-194.

42. Villers A, Godaux E, Ris L (2012) Long-Lasting LTP Requires Neither Repeated Trains for Its Induction Nor Protein Synthesis for Its Development. PLoS ONE 7(7): e40823. doi:10.1371/journal.pone.0040823



41. Bartlett TE, Lu J and Wang YT  (2011)  Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression.  Mol. Brain, 4:41.

40. Bouet V, Freret T, Dutar P, Billard J-M, Boulouard M (2011) Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals. Mechanisms of Ageing and Development, 132:240-248.

39. Caruana DA, Warburton ED, Bashir ZI (2011) Induction of Activity-Dependent LTD Requires Muscarinic Receptor Activation in Medial Prefrontal Cortex. J. Neurosci., 31:18464-18478.

38. Ceolin L, Kantamneni S, Barker GRI, Hanna L, Murray L, Warburton EC, Robinson ESJ, Monn JA, Fitzjohn SM, Collingridge GL,  Bortolotto ZA and Lodge D  (2011)  Study of Novel Selective mGlu2 Agonist in the Temporo-Ammonic Input to CA1 Neurons Reveals Reduced mGlu2 Receptor Expression in a Wistar Substrain with an Anxiety-Like Phenotype.  J. Neurosci., 31:6721– 6731.

37. Errico F, Nisticò R, Napolitano F, Mazzola C, Astone D, Pisapia T, Giustizieri M, D’Aniello A, Mercuri NB, Usiello A  (2011)  Increased d-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice.  Neurobiol. Aging, 32:2229–2243.

36. Escobar M , Crouzin N , Cavalier M , Quentin J , Roussel J , Lanté F , Batista-Novais AR , Cohen-Solal C , De Jesus Ferreira M-C , Guiramand J , Barbanel G and Vignes M  (2011)  Early, Time-Dependent Disturbances of Hippocampal Synaptic Transmission and Plasticity After In Utero Immune Challenge.  Biol. Psychiatry, 70:992–999.

35. Gan J, Greenwood SM, Cobb SR and Bushell TJ  (2011)  Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2.  Brit. J. Pharmacol, 163:984-994.

34. Kim J-I, Lee H-R, Sim S, Baek J, Yu N-K, Choi J-H, Ko H-G, Lee Y-S, Park S-W, Kwak C, Ahn S-J, Choi SY, Kim H, Kim K-H,  Backx PH, Bradley CA, Kim E, Jang D-J, Lee K, Kim SJ, Zhuo M, Collingridge GL and Kaang B-K  (2011)  PI3Kg is required for NMDA receptor–dependent long-term depression and behavioral flexibility.  Nature Neuroscience, 14:1447–1454.

33.  Koch S, Molchanova SM, Wright AK, Edwards A, Cooper JD, Taira T, Gillingwater TH, Tyyne J (2011) Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis. J. Neuropathology & Experimental Neurology, 70:1089-1096.

32. Min J-A, Lee H-R, Kim J-I, Jub A, Kim D-J, Kaang B-K  (2011)  Impairment of long-term potentiation in the hippocampus ofalcohol-treated OLETF rats.  Neuroscience Letters, 500:52-56.

31. Moult PR and Harvey J  (2011)  NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity.  Neuropharmacology, 61:924-936.

30. Sanderson TM, Collingridge GL and Fitzjohn SM  (2011)  Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs  Molecular Brain, 4:30.

29. Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH and Craig AM  (2011)  Postsynaptic TrkC and Presynaptic PTPs Function as a Bidirectional Excitatory Synaptic Organizing Complex.  Neuron, 69, 287–303.

28. Weng S-M, McLeod F, Bailey MES and Cobb SR (2011)  Synaptic Plasticity Deficits in an Experimental Model of Rett Syndrome: Long-Term Potentiation Saturation and its Pharmacological Reversal.  Neuroscience 180:314–321.



27. Armogida M, Giustizieri M, Zona C, Piccirilli S, Nisticò R, Mercuri NB  (2010)  N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: An in vitro electrophysiological study.  Synapse, 64:161-168.

26. Potier B, Billard J-M, Rivière S, Sinet P-M, Denis I, Champeil-Potokar G, Grintal B, Jouvenceau A, Kollen M, Dutar P  (2010)  Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats.  Aging Cell, 9:722–735.

25. Hoffman AF, Laaris N, Kawamura M, Masino SA, Lupica CR  (2010)  Control of Cannabinoid CB1 Receptor Function on Glutamate Axon Terminals by Endogenous Adenosine Acting at A1 Receptors.  J. Neurosci., 30:545-555.

24. Jo J, Son GH, Winters BL, Kim MJ, Whitcomb DJ, Dickenson BA, Lee Y-B, Futai K, Amici M, Sheng M, Collingridge GL and Cho K  (2010)  Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.  Nature, 13:1216–1224.

23. Kamsler A, McHugh TJ, Gerber D, Huang SY, Tonegawa S  (2010)  Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus.  PNAS, 107:1618-1623.

22. Lagostena L, Rosato-Siri M, Onofrio M, Brandi R, Arisi I, Capsoni S, Franzot J, Cattaneo A, Cherubini E  (2010)  In the Adult Hippocampus, Chronic Nerve Growth Factor Deprivation Shifts GABAergic Signaling from the Hyperpolarizing to the Depolarizing Direction.  J. Neurosci., 30:885-893.

21. Moult PR, Cross A, Santos SD, Carvalho A-L, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J  (2010)  Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition.  J. Neurosci., 30:4088-4101.

20. Villers A, Godaux E, Ris L  (2010)  Late phase of L-LTP elicited in isolated CA1 dendrites cannot be transferred by synaptic capture.  NeuroReport, 21:210-215.



19. Dargan SL, Clarke VRJ, Alushin GM, Sherwood JL, Nistico R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL  (2009)  ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function.  Neuropharmacol., 56:121-130.

18. Hong I, Song B, Lee S, Kim J, Kim J, Choi S  (2009)  Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala.  Eur. J. Neurosci., 30:2089-2099.

17. Karlen A, Karlsson TE, Mattsson A, Lundstromer K, Codeluppi S, Pham TM, Backman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, Brene S, Olson L  (2009)  Nogo receptor 1 regulates formation of lasting memories.  PNAS, 106:20476-20481.

16. Kim J, Park S, Lee S and Choi S  (2009)  Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis.  Neuroreport, 20:517-520.

15. Lagostena L, Danober L, Challal S, Lestage P,  Mocaër E, Trocmé-Thibierge C, Cherubini E  (2009)  Modulatory effects of S 38232, a non α-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus.  Neuropharmacol., 58:806-815.

14. Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A  (2009)  Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine.  Brain, 132:2336-2349.

13. Omrani A, Melone M, Bellesi M, Safiulina V, Aida T, Tanaka K, Cherubini E, Conti F  (2009)  Up-regulation of GLT-1 severely impairs LTD at mossy fibre-CA3 synapses.  J. Physiol., 587:4575-4587.

12. Peineau S, Nicolas CS, Bortolotto ZA, Bhat RV, Jonathan Ryves W, Harwood AJ, Dournaud P, Fitzjohn SM, Collingridge GL  (2009)  A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases.  Mol. Brain, 2:22 (10 pages).

11. Ris L, Villers A, Godaux E  (2009)  Synaptic capture-mediated long-lasting long-term potentiation is strongly dependent on mRNA translation.  NeuroReport, 20:1572-1576.

10. Sallert M, Rantamaki T, Vesikansa A, Anthoni H, Harju K, Yli-Kauhaluoma J, Taira T, Castren E, Lauri SE  (2009)  Brain-Derived Neurotrophic Factor Controls Activity-Dependent Maturation of CA1 Synapses by Downregulating Tonic Activation of Presynaptic Kainate Receptors.  J. Neurosci., 29:11294-11303.

9. Seoane A, Massey PV, Keen H, Bashir ZI, Brown MW  (2009)  L-Type Voltage-Dependent Calcium Channel Antagonists Impair Perirhinal Long-Term Recognition Memory and Plasticity Processes.  J. Neurosci., 29:9534-9544.

8. Zadran S, Qin Q, Bi X, Zadran H, Kim Y, Foy MR, Thompson R, Baudry M  (2009)  17-β-Estradiol increases neuronal excitability through MAP kinase-induced calpain activation PNAS, 106:21936-21941.



7. Fernandes CC, Pinto-Duarte A, Ribeiro JA, and Sebastiao AM  (2008)  Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.  J. Neurosci., 28:5611–5618.

6. Jo J, Heon S, Kim MJ, Son GH, Park Y, Henley JM, Weiss JL, Sheng M, Collingridge GL and Cho K  (2008)  Metabotropic Glutamate Receptor-Mediated LTD Involves Two Interacting Ca2+ Sensors, NCS-1 and PICK1.  Neuron, 60:1095-1111.

5. Lagostena L, Trocme-Thibierge C, Morain P and Cherubini E  (2008)  The partial a7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus.  Neuropharmacol., 54:676-685.

4. Giustizieri M, Armogida M, Berretta N, Federici M, Piccirilli S, Mercuri NB, Nistico R (2008)  Differential effect of carbamazepine and oxcarbazepine on excitatory synaptic transmission in rat hippocampus. Synapse 62:783–789.

3. Biber K, Pinto-Duarte A, Wittendorp MC, Dolga AM, Fernandes CC, Von Frijtag Drabbe Kunzel J, Keijser JN, de Vries R, Ijzerman AP, Ribeiro JA, Eisel U, Sebastião AM and Boddeke HWGM  (2008)  Interleukin-6 upregulates neuronal Adenosine A1 receptors: Implications for neuromodulation and neuroprotection.     Neuropsychopharmacol., 33:2237-2250.



2. Lanté F, Meunier J, Guiramand J, Maurice T, Cavalier M, de Jesus Ferreira MC, Aimar R, Vignes M and Barbanel G (2007)  Neurodevelopmental damage after prenatal infection: Role of oxidative stress in the fetal brain.  Free Radical Biology and Medicine, 42:1231–1245.

1.  Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JTR, Bortolotto ZA, Wang YT, Collingridge GL  (2007)  UP inhibits LTD in the hippocampus via regulation of GSK3 beta. Neuron, 53:703-717.



LTP Program

The LTP Program has been used in at least 381 publications.  


None yet.



381.  Fusco I, Cherchi F, Catarzi D, Colotta V, Varano F, Pedata F, Pugliese AM and Coppi E  (2019)  Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus. Brain Research Bulletin, 151:174-180;

380.  Martire A, Lambertucci C, Pepponi R, Ferrante A, Benati N, Buccioni M, Ben DD, Marucci G, Klotz K-N, Volpini R and Popoli P  (2019)  Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia. Journal of Neurochemistry, ttps://

379.  Ryskamp D, Wu L, Wu J, Kim D, Rammes G, Geva M, Hayden M and Bezprozvanny I  (2019)  Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.   Neurobiology of Disease, 124:489-504;



378.  Coppi E, Lana D, Cherchi F, Fusco I, Buonvicino D, Urru M, Ranieri G, Muzzi M, Iovino L, Giovannini MG, Pugliese AM and Chiarugi A  (2018)  Dexpramipexole enhances hippocampal synaptic plasticity and memory in the rat. Neuropharmacology, 143:306-316.

377.  Dias RB, Rodrigues TM, Rombo DM, Ribeiro FF, Rodrigues J, McGarvey J, Orcinha C, Henley JM, Sebastião AM  (2018)
Erythropoietin Induces Homeostatic Plasticity at Hippocampal Synapses.  Cerebral Cortex, 28:2795–2809,

376.  Fusco I, Ugolini F, Lana D, Coppi E, Dettori I, Gaviano L, Nosi D, Cherchi F, Pedata F, Giovannini MG and Pugliese AM  (2018)  The selective antagonism of adenosine A2B receptors reduces the synaptic failure and neuronal death induced by oxygen and glucose deprivation in rat CA1 Hippocampus in Vitro.  Frontiers in Pharmacology, 2018; 9: 399;doi:10.3389/fphar.2018.00399.

375.  Rammes G, Seeser F, Mattusch K, Zhu K, Haas L, Kummer M, Heneka M, Herms J and Parsons CG  (2018)  The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aß) species on long-term potentiation (LTP).  Neuropharmacology, 140:184-192.

374.  Tanqueiro SR, Ramalho RM, Rodrigues TM, Lopes LV, Sebastião AM and Diógenes MJ  (2018)  Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid ß. Frontiers in Pharmacology,



373.  Aidil-Carvalho MF, Carmo AJS, Ribeiro JA and Cunha-Reisa D  (2017)  Mismatch novelty exploration training enhances hippocampal synaptic plasticity: A tool for cognitive stimulation?  Neurobiology of Learning and Memory, 145:240–250;

372.  Bhagya VR, Srikumar BN, Veena J, Rao BSS  (2017)  Short-term exposure to enriched environment rescues chronic stress-induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits.  J. Neurosci. Res., 95:1602-1610;

371.  Dias RB, Rodrigues TM, Rombo DM, Ribeiro FF, Rodrigues J, McGarvey J, Orcinha C, Henley JM and Sebastião AM (2017)  Erythropoietin Induces Homeostatic Plasticity at Hippocampal Synapses.  Cerebral Cortex,

370.  Ling Y-Z, Li Z-Y, Ou-Yang H-D, Ma C, Wu S-L, Wei J-Y, Ding H-H, Zhang X-L, Liu M, Liu C-C, Huang Z-Z, Xin W-J (2017)  The inhibition of spinal synaptic plasticity mediated by activation of AMP-activated protein kinase signaling alleviates the acute pain induced by oxaliplatin.  Experimental Neurology, 288:85-93;

369.  Poli D, Falsini M, Varano F, Betti M, Varani K, Vincenzi F, Pugliese AM, Pedata F, Ben DD, Thomas A, Palchetti A, Bettazzi F, Catarzi D and Colotta V  (2017)  Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes.  European Journal of Medicinal Chemistry, 125:611-628;

368.  Rammes G, Mattusch C, Wulff M, Seeser F, Kreuzer M, Zhu K, Deussing JM, Herms J and Parsons CG  (2017)Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aß) in murine models of Alzheimer's disease (AD).  Neuropharmacology, 123:100-115;

367.  Santos VV, Stark R, Rial D, Silva HB, Bayliss JA, Lemus MB, Davies JS, Cunha RA, Prediger RD and Andrews ZB (2017)  Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid ß (Aß1-40) administration in mice.  Journal of Neuroendocrinology, vol 29;

366.  Wei J-Y, Liu C-C, Ouyang H-D, Ma C, Xie M-X, Liu M, Lei W-L, Ding H-H, Wu S-L and Xin W-J  (2017)  Activation of RAGE/STAT3 pathway by methylglyoxal contributes to spinal central sensitization and persistent pain induced by bortezomib.  Experimental Neurology, 296:74-82;

365.  Xu T, Li D, Zhou X, Ouyang H-D, Zhou L-J, Zhou H, Zhang H-M, Wei X-H, Liu G and Liu X-G  (2017)  Oral Application of Magnesium-l-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-a/Nuclear Factor-?B Signaling.  Anesthesiology, 126:1151-1168; doi:10.1097/ALN.0000000000001601.

364.  Xu T, Zhang X-L, Ou-Yang, H-D, Li Z-Yu, Liu C-C, Huang Z-Z, Xu J, Wei J-Y, Nie B-L, Ma C, Wu S-L and Xin W-J (2017)  Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics–induced neuropathic pain. Pain, 158:637–648; doi: 10.1097/j.pain.0000000000000805.

363.  Zhou Y, Wang Z, Xia M, Zhuang S, Gong X, Pan J, Lia C, Fan R, Pang Q and Lu S  (2017)  Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: Implications for children exposed to environmental levels of BPA. Environmental Pollution, 229:40-48,



362.  Abouelela A and Wieraszko A  (2016)  The Influence of Glutamate on Axonal Compound Action Potential In Vitro.  J. Brachial Plexus Peripheral Nerve Injury, 11:e29–e37; doi:10.1055/s-0036-1593441.

361.  Capsoni S, Malerba F, Carucci NM, Rizzi C, Criscuolo C, Origlia N, Calvello M, Viegi A, Meli G and Cattaneo A (2016)The chemokine CXCL12 mediates the anti-amyloidogenic action of painless human nerve growth factor.  Brain, 140:201–217;

360.  Lemos C, Rial D, Gonçalves FQ, Pires J, Silva HB, Matheus FC, da Silva AC, Marques JM, Rodrigues RJ, Jarak I, Prediger RD, Reis F, Carvalho RA, Pereira FC and Cunha RA  (2016)  High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus. Neuroscience, 315:196-205;

359.  Mahati K, Bhagya V, Christofer T, Sneha A and Rao BSS  (2016)  Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity.  Neurobiology of Learning and Memory, 134:379-391;

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